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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5929) Last page : ( 5934)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01035.5

Improving the technology of obtaining an inactivated antirabic vaccine from CVS-11 strain

Abdualiyeva A. A.1*, Akhmetsadykov N. N.2, Valdovska A.3, Shanbaev B. U.2

1Kazakh National Agrarian University, Kazakhstan.

2Scientific-Production Enterprise "Antigen", Kazakhstan.

3Latvian Agricultural University, Latvia.

*Corresponding Author E-mail: asem.a.86@mail.ru

Online published on 15 February, 2021.

Abstract

Developing an effective and high-quality vaccine is an important issue in rabies prevention. This article presents the results of the studies aimed at selecting the optimum parameters for the cultivation of the VN-21 finite cell line and the CVS-11 strain of the rabies virus. Such parameters as inoculated cell concentration, the optimal dose of infection with the virus, the time and methods of cultivation, and the choice of the inactivant and the adjuvant were chosen.

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Keywords

Rabies virus, Cultivation, Vaccine, Adjuvant, Completeness of inactivation.

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