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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5909) Last page : ( 5913)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01031.8

Formulation development and invitro evaluation of elvitegravir sustained release using solid dispersions

Sulthana Mohammad Akthar1, Kethavath Mangulal Dr.2, Ahmad Fazil Dr.3, Al-Subaie Abeer Mohammed Dr.4

1Department of Pharmaceutics, SLC College of Pharmacy. Address, Piglipur (V) Near Ramoji Film City, Hayathnagar (Dist)-501512, Telangana, India.

2Assistant Professor, Department of Pharmaceutics, SLC College of Pharmacy. Address, Piglipur (V) Near Ramoji Film City, Hayathnagar (Dist)-501512, Telangana, India.

3Assistant Professor, Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, P.O. Box 4030, Jubail, Saudi Arabia.

4Assistant Professor of Haematology, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Saudi Arabia.

*Corresponding Author E-mail: aktharsulthana95@gmail.com

Online published on 15 February, 2021.

Abstract

The aim of the present study is to formulate Sustained release tablets of elvitegravir solid dispersions. The enhancement of oral bioavailability of poorly water soluble drugs like Elvitegravir could be improved by enhancing aqueous solubility. Among numerous ways of enhancing drug dissolution, solid dispersions and inclusion complexation are promising techniques to enhance the dissolution of poorly water soluble drugs. The calibration curve of Elvitegravir was obtained in the range of 2–10μg at the wavelength of 313 nm. It has shown good linearity with a regression coefficient of 0.999 (r2 value). This result exhibit a direct relationship between concentration of polymers and drug release. Among the various formulations tablets of batch E2 prepared with 40mg Guar gum showed complete release of drug within 24 hrs.

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Keywords

Sustained release tablets, Elvitegravir, Aqueous solubility, Complexation, Guar gum.

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