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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5851) Last page : ( 5854)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01019.7

In vitro antidiabetic activity of hydroalcoholic leaf extract of Cucumis melo var agrestis (Cucurbitaceae)

Gopalasatheeskumar K.1*, Kalaichelvan V.K.1, Ariharasivakumar G.2, Sengottuvel T.2, Devan V. Sanish2

1department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu-608002, India.

2Department of Pharmacology, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore -641048, Tamil Nadu, India (Affiliated to The Tamil Nadu Dr. M.G.R. Medical University).

*Corresponding Author E-mail: gskpungai@gmail.com

Online published on 15 February, 2021.

Abstract

Background: Diabetes is a group of metabolic diseases characterized by high levels of blood sugar (hyperglycemia). Many of the antidiabetic drugs available to treat diabetes but they have the side effects so that finding of alternatives is important in diabetic research. Cucumis melo var agrestis (CMA) is under the family of Cucurbitaceae, many of the cucurbitacae family plants has reported as antidiabetic activity but still there is no reports on antidiabetic activity on CMA. Aim and Objectives: The present study is aimed to that evaluation of in vitro antidiabetic activities of hydroalcoholic leaf extract of Cucumis melo var agrestis (HALEC). Methods: The antidiabetic activity was evaluated by hemoglobin glycosylation Inhibition assay, Alpha amylase inhibition assay, alpha glucosidase inhibitory assay, Glucose uptake in yeast cells, Glucose diffusion assay and glucose adsorption capacity. Results: Our results revealed that HALEC has potent antidiabetic activities it was compared with standard acarbose and metformin. Conclusion: From the results of this research the HALEC has the antidiabetic activity and further study needed to animal studies and finding of exact mechanism.

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Keywords

Cucumis melo subsp. Agrestis, Hypoglycemic, Glucose uptake, Acarbose, Metformin.

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