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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5837) Last page : ( 5843)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01017.3

Synthesis and biological evolution N-(R1-phenyl)-5-(R-phenyl)-2-furamides

Matiichuk Y.E.1, Sulyma M.I.1, Chaban T.I.1*, Ogurtsov V.V.1, Matiychuk V. S.2

1department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine.

2Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla and Mefodia, Lviv, 79005, Ukraine.

*Corresponding Author E-mail: chabantaras@ukr.net

Online published on 15 February, 2021.

Abstract

By the reaction of furan-2-carboxylic acids with diazonium salts 1a-e the arylfuran-2-carboxylic acids 3a-e were synthesized. Acids 3a-e were transformed into appropriated acylchlorides 4a-e and were used for preparation of N-(R1-phenyl)-5-(R-phenyl)-2-furamides 6a-k. The structures of target compounds 6a-k were confirmed by using 1H NMR spectroscopy and elemental analysis. The compounds 6d-f with high antimicrobial activity against C. Neoformans ATCC 208821 were identified. It also have been found that compound 6i to be high active and against PC-3 Prostate Cancer cell lines (GP = 34.42) and 6f SR Leukemia cell lines (GP = 59.81).

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Keywords

Organic synthesis, Furan, N-(R1-phenyl)-5-(R-phenyl)-2-furamides, Pharmacological screening, Antimicrobial activity, Anticancer activity.

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