Effects of quercetin and kaempferol (Main Compound of Moringa oleifera leaves) improve IUGR through decreased hypoxia Batmomolin Agnes12*, Khotimah Husnul13, Ahsan Ahsan14, Wiyasa I. Wayan Arsana15, Santoso Sanarto16 1Doctoral Program of Medical Science, Faculty of Medicine Universitas, Brawijaya, Indonesia. 2Moluccas Polytechnic of Health, Jakarta, Indonesia. 3Department of Pharmacology, Faculty of Medicine Universitas, Brawijaya, Indonesia. 4Nursing Study Program, Faculty of Medicine Universitas, Brawijaya, Indonesia. 5Department of Obstetrics and Gynecology, Saiful Anwar Public Hospital, Malang, Indonesia. 6Department of Microbiology, Faculty of Medicine Universitas, Brawijaya, Indonesia. *Corresponding Author E-mail: agnesbat4@gmail.com
Online published on 15 February, 2021. Abstract Preeclampsia (PE) is special multisystem disorder that due deficient spiral artery remodeling and placental hypoxia with main symptom is hypertension and proteinuria. Deficient spiral artery remodeling can reduce blood flow from maternal to the fetus, therefore occur intrauterine growth restriction and low birth weight babies. Moringa oleifera leaves (MOL) are rich of nutrients, also can be used for medicine. The aim of this study is to evaluate effect of main compounds of ethanol extract MOL to improve IUGR by evaluate rat pups weight and predict the interaction of the main compound of MOL namely Quercetin and Kaempferol on hypoxia and angiogenesis as an approach to prevent preeclampsia. The methods of this research was experimental post-test only control group design and web based: PubChem was used to identify the compound structure and format data SMILE, Swiss target prediction for proteins target prediction, PASS SERVER to predict biological activity of the compounds, while STITCH was used to predict the interaction of compounds with protein target. The result showed that ethanol extract of MOL with the main compound quercetin and kaempferol improve IUGR that shown by increase rat pups weight in administered ethanol extract of MOL group compared to preeclampsia group, MOL extract have the same effect to prevent decrease rat pups weight. In predict main compounds MOL, both of compounds have good biological activity (pa>0.7), target protein prediction = 0.9 to maintain the function of endothelial blood vessel and inhibit hypoxia. Both of compounds work synergistically on hypoxia and angiogenesis through activation and inhibition of HIF-1A. Top Keywords IUGR, Hypoxia, Angiogenesis, Quercetin, Kaempferol, Preeclampsia. Top |