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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5811) Last page : ( 5815)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01013.6

Cancer Chemopreventive effect of Rodent Tuber (Typhonium flagelliforme (Lood) Bl) against DMBA-Induced Rats Breast Tumor

Maysarah Hilda1, Faradilla Meutia1, Sari Irma1, Illian Didi Nurhadi1*

1Department of Pharmacy, Faculty of Mathematics and Natural Science, Syiah Kuala University, Banda Aceh23111, Indonesia.

*Corresponding Author E-mail: didinurhadi40@gmail.com

Online published on 15 February, 2021.

Abstract

Rodent tuber (Typhonium flagelliforme (Lood) Bl) has been known and used as a food supplement for an alternative cancer therapy and tumors, including breast tumors. Numerous in vitro studies were exhibited an anticancer activity of this plant compound against several cancer cells, hence the present study as a further in vivo research to determine its cancer chemopreventive activity. The survival rate of animals, latency period of tumors, percentage of tumor incidence, number and size of tumors, weight of tumors, fluorescence intensity of autofluorosphore (FIA) and histological evaluation were investigated. The extracts of T. flagelliforme were obtained by maceration using 95% ethanol and condensed utilize rotary evaporator. The chemopreventive effect of T. flagelliforme was determined by observing the activity of these extract toward female Sprague-Dawley rats induced breast tumor using single dose of 15mg of 7,12-dimethylbenz (a) anthracene (DMBA) per rat (given orally). Rats given only DMBA were used as a control group. T. flagelliforme extract (50mg/kg bw) given for 7 days before and after induction (test group). The results showed that whole animal of chemopreventive group were survived and the group given T. flagelliforme extract (50mg/kg bw) were reduced latency period of tumors at 12 weeks compared to the control group at 9 weeks. The percentage of tumor incidence, number and size of tumors (33.33%; 0.50 and 0.39 cm2) were exhibited significantly different compared to the control group (100%; 2.83 and 2.4cm2), respectively (p < 0.001). The weight of tumors and FIA values were revealed significantly different (0.26g and 6.00) compared to control group (5.34g and 11.62), respectively. Furthermore, histological evaluation was demonstrated that the test group (given T. flagelliforme extract) had a different histopathologic figure and malignancy level compared to the control group. The conclusion exhibited that T. flagelliforme extract can be used as cancer chemopreventive against breast tumor.

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Keywords

Rodent tuber, Typhonium flagelliforme, Cancer chemopreventive, Breast tumor, DMBA.

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