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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5749) Last page : ( 5753)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.01001.X

Quantitative analysis of combined analgetic tablets

Yunusova Kholida1, Ravshanova Sevara1*

1Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute, Aybek 45, 100015, Tashkent, Uzbekistan.

*Corresponding Author E-mail: sravshanova@gmail.com

Online published on 15 February, 2021.

Abstract

This study aimed to develop a method for the quantitative determination of active medicinal substances that are part of a combined analgesic tablet under the code name "Analfenon". We previously developed technology obtaining combined ternary tablets with a potential analgesic effect which contains metamizole sodium, drotoverin hydrochloride, diphenhydramine hydrochloride. The amount of metamizole sodium, drotaverine hydrochloride, diphenhydramine hydrochloride was analyzed by methods spectrophotometry and titrimetry. Using the developed technique, the content of metamizole sodium, drotoverin hydrochloride, diphenhydramine hydrochloride in 5 samples was determined. The results of the quantitative analysis were evaluated using the metrological analysis. The results showed that the active drugs contained in the tablet are within the limits specified in the normative technical document. The proposed methods for the analysis of analgesic combined tablets provide reliable and well reproducible results. The developed methods formed the basis of regulatory documentation for a new analgesic drug-Analfenon tablets.

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Keywords

Non-narcotic analgesics, Combined analgesic tablets, Spectrophotometric analysis, An active pharmaceutical ingredient (APhI).

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