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Year : 2020, Volume : 13, Issue : 12
First page : ( 5736) Last page : ( 5742)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00999.3

Effect of encapsulated Lactobacillus rhamnosus GG in antibiotic associated diarrhea in albino wistar rat model

Chauhan Seema B.1, Singh Vinod2, Chauhan Rajani3*

1Department of Pharmaceutical Sciences, Banasthali Vidyapith, Vanasthali, Rajasthan, India.

2Department of Pharmaceutical Sciences, Gurukul Kangri University, Haridwar, Uttar PradeshUttarakhand, India.

3Department of Pharmaceutical Sciences, Banasthali Vidyapith, Vanasthali, Rajasthan, India.

*Corresponding Author E-mail: rajanichauhan_pharma@yahoo.com

Online published on 15 February, 2021.


Probiotics are the beneficial microorganism possesses many health benefits for human being upon their use. The major limitation in the use of probiotics is their loss of viability during storage as well during passage through the upper gastrointestinal tract. Probiotic encapsulation technology has the potential to protect microorganisms and to deliver them into the gut. In order to overcome the limitation of viability in upper gastrointestinal tract, Lactobacillus Rhamnosus GG encapsulated pectin and sodium carboxy methyl cellulose microbeads of probiotics: polymer ratio (1:1, 1:2 and 1:3) were fabricated using the ionotropic gelation technique. In addition, the developed microbeads were coated with Eudragit S 100 and cellulose acetate phthalate and assessed in vivo anti-diarrheal activity and compared with free probiotics. The developed microbeads have shown increase of probiotics: polymer ratio significantly improves viability of probiotics and therefore shown quick onset of action with encapsulated microbeads as compared to free probiotics. Thus, coated microbeads could be a potential delivery system for treatment of antibiotic associated diarrhea.



Antibiotic associated diarrhea, Probiotics, Lactobacillus rhamnosus GG, Encapsulation, Wistar rat.


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