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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2020, Volume : 13, Issue : 12
First page : ( 5705) Last page : ( 5710)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00993.2

Synthesis and in vitro evaluation of pyridincarbonitrile mercaptobenzimidazole derivatives as a potent biological agent

Kardile Deepak1*, Shirsat Mrunal1

1Department of Pharmaceutical Sciences, Madhav University, Pindwara-307026, (Rajasthan) India.

*Corresponding Author E-mail: kardiledeepak@gmail.com

Online published on 15 February, 2021.

Abstract

In this present investigation to study of novel pyridincarbonitrile mercaptobenzimidazole derivatives was efficiently synthesized, which is further characterized and authenticated by using TLC, different spectral data such as IR and 1HNMR. The newly synthesized derivatives were tested against in vitro antimicrobial and antitubercular activities. The result shows that the titled compounds shown average antibacterial activity against gram-positive Bacillus Subtilis, gram-negative Escherichia Coli as compared to standard ciprofloxacin. Compounds DPK4B1d2 and DPK4B1d7 shown potent antifungal activity against Aspergillus Niger as compared to standard fluconazole. Antitubercular activity tested against mycobacterium tuberculosis, compound DPK4B1d2 showed potent activity and also, rest of the compounds showed moderate activities in the comparison of standard such as Pyrazinamide, Ciprofloxacin, and Streptomycin.

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Keywords

Pyridincarbonitrile Mercaptobenzimidazole, Antimicrobial, Antitubercular.

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