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Year : 2020, Volume : 13, Issue : 12
First page : ( 5692) Last page : ( 5698)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00991.9

Optimization of soybean oil, tween 80, PEG 400 in formulation of beta carotene nanoemulsion

Kresnawati Yani13, Shantiningsih Rurie Ratna2, Martien Ronny1*

1Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta55281, Indonesia.

2Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta55281, Indonesia.

3Yayasan Pharmasi College of Pharmacy, Semarang50193, Indonesia.

*Corresponding Author E-mail: ronnymartien@ugm.ac.id

Online published on 15 February, 2021.


Beta carotene in the form of patch gingival can reduce the number of micronucleus in rabbit gingival mucosa due to X-ray radiation. Beta carotene has water soluble properties and low bioavailability. One strategy to overcome this is to formulate it in the form of nanoemulsion. Optimization of beta carotene nanoemulsion formula with the composition of soybean oil, tween 80, PEG 400 is done by the D-Optimal method using Design Expert 10 software with response to drug loading, emulsification time, transmittance value. The optimum beta carotene nanoemulsion then is characterized in the form of zeta potential, droplet size, polydispersity index. The optimum formula of beta carotene nanoemulsion was obtained from a composition of 10% soybean oil, tween 80 79.06%, and PEG 400 10.94% with a drug loading value of 2.81±0.04mg, emulsification time of 51.33±3.21 seconds, percent of clarity 94.06 ± 0.06%, droplet size of 11.36±1.03nm, polydispersity index of 0.665±0.04, and potential zeta of -12.1 ± 1.04 mV. D-optimal could be proved as suitable method for determining the optimum conditions that was capable of produced drug loading response, emulsification time, percent clarity of beta carotene nanoemulsion.



Beta Carotene, Nanoemulsion, X-Ray Radiation, D-Optimal, Soybean Oil.


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