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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 10
First page : ( 5026) Last page : ( 5033)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00880.X

Synthetic procedures and pharmacological activities of 1,2,4-oxadiazoles-a review

Aggarwal Sunaina1, Goyal Anju*, Kaur Rajwinder2

1R.K.S.D. College of Pharmacy, Kaithal, Haryana-136027

2Chitkara College of Pharmacy, Chitkara University, Punjab, India

*Corresponding Author E-mail: anju_goyal2003@rediffmail.com; anju.goyal@chitkara.edu.in

Online published on 28 October, 2020.


Five membered heterocyclic ring structures, oxadiazoles contain one oxygen and two nitrogen atoms. The synthesis of 1,2,4-oxadiazole involves conversion of cyanide to hydroxyl amine followed by 1,3-dipolar cycloaddition reaction to form a ringed structure. Ring also acts as bioisostere for carboxylic acid and carboxamide group. Further 1,2,4-oxadiazole derivatives have been evaluated for a wide range of medicinal applications.



1, 2, 4-Oxadiazole, Amidoximes, Bioisosterism, Anticancer.


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