Synthetic procedures and pharmacological activities of 1,2,4-oxadiazoles-a review Aggarwal Sunaina1, Goyal Anju*, Kaur Rajwinder2 1R.K.S.D. College of Pharmacy, Kaithal, Haryana-136027 2Chitkara College of Pharmacy, Chitkara University, Punjab, India *Corresponding Author E-mail: anju_goyal2003@rediffmail.com; anju.goyal@chitkara.edu.in
Online published on 28 October, 2020. Abstract Five membered heterocyclic ring structures, oxadiazoles contain one oxygen and two nitrogen atoms. The synthesis of 1,2,4-oxadiazole involves conversion of cyanide to hydroxyl amine followed by 1,3-dipolar cycloaddition reaction to form a ringed structure. Ring also acts as bioisostere for carboxylic acid and carboxamide group. Further 1,2,4-oxadiazole derivatives have been evaluated for a wide range of medicinal applications. Top Keywords 1, 2, 4-Oxadiazole, Amidoximes, Bioisosterism, Anticancer. Top |