(18.97.9.170)
[ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 10
First page : ( 4973) Last page : ( 4980)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00872.0

Pilot plant scale up for tablet

Sharma Saloni*, Patil Amit B.**, Gowda DV***

Department of Industrial Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka - 560078, India

*Corresponding Author E-mail: salpalrockzz@gmail.com

**amitbpatil@jssuni.edu.in

***dvgowda@jssuni.edu.in

Online published on 28 October, 2020.

Abstract

The manufacture of oral dosage forms is a complex process in which the starting material of API is converted into the final product by the manufacturing and processing into different physical properties in order to produce the final product. The initial step for tabletting is the process of granulation under which is the dry and wet granulation. Following the process parameters of bioavailability and stability of the product it is related to the content uniformity. The next step is the powder blending property which is supported by the pre and post blending processes in the manufacturing process itself. The process parameters used here are mixing time and blending speed. All the initial steps should be evaluated at the manufacturing and the beginning stage itself. The quality and quantity of the lubricant used plays an important role in the quality of the final product. Furthermore, is the step of drying to irradiate the moisture content in the product, hence increases the free flowing properties of the product powdered particles. The final step of the tabletting process tablet compression. There should be no impressions present in and around the tablet for a good stabilised final product.

Top

Keywords

Bioavailability, Stability, Manufacturing, Lubricant.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
861,555,815 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.