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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 10
First page : ( 4836) Last page : ( 4838)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00851.3

Development and validation of uv spectroscopic method for the determination of sonidegib in bulk and pharmaceutical dosage form

Murugan S12*, Vetrichelvan T1

1Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Tamilnadu, India

2Research Scholar, The Tamilnadu Dr. M.G.R. Medical University, Chennai-600032, Tamilnadu, India

*Corresponding Author E-mail: msm_apcp07@yahoo.com

Online published on 28 October, 2020.

Abstract

Two simple UV method was developed for the determination of sonidegib in bulk and pharmaceutical dosage form. The method involves the Zero and First order derivative. Sonidegib has λmax 277nm in zero order. In first order the wavelength selected was 293nm. The methods were found to be linear between the range of 3-15μg/ml for Sonidegib in methanol. The Zero and First-order derivative methods shows good linearity in the above concentration range and correlation coefficient is 0.9994 and 0.9998, respectively.

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Keywords

Sonidegib, UV Method, Zero order, First order.

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