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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 10
First page : ( 4711) Last page : ( 4714)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00829.X

Simultaneous estimation of halobetasol propionate and tazarotene in pure and dosage form by using uv-visible spectrophotometric method

Kumar Avichal, Goyal Kamya, Pandit Vinay, Ashawat MS, Jindal Shammy*

Laureate Institute of Pharmacy, Kathog, Jwalamukhi, Himachal Pradesh, India-176031

*Corresponding Author E-mail: shammyjindal@gmail.com

Online published on 28 October, 2020.


The easy, simple and rapid spectrophotometric method (simultaneous equation method) have been generate for Halobetasol and Tazarotene drugs. These drugs are available in the form of gel, lotion, creams etc. The absorbance spectrum (λ-max) of Halobetasol propionate was found to be 238nm and Tazarotene was found to be 352nm. The linearity of both Halobetasol and Tazarotene was found between 2-10μg/mL. The precision as well as accuracy of the developed method was performed statically. The reproducibility of the developed method was good, whereas recovery in %RSD is less than 1. From the analytical and statistical data of this developed method, it was concluded that this method is useful for laboratory spectrophotometric analysis of Halobetasol and Tazarotene from given formulation samples. The aim of doing this research work is due to the combination formulation phase-3 trial is in progress for both of these drugs. The Halobetasol is topical corticosteroid whereas Tazarotene is third generation topical retinoid. The purpose of the combinational formulation is to develop potent treatment for skin diseases like psoriasis. To decrease or avoiding the adverse effects of Halobetasol like skin roughness, skin dryness, itching, Tazarotene was selected in combination because of its counter effects on the adverse effect of Halobetasol.



Halobetasol, Tazarotene, Simultaneous equation method, Linearity, Precision, LOD, LOQ.


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