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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 10
First page : ( 4625) Last page : ( 4628)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00814.8

Spectrophotometric determination of Sulfasalazine drug in pure and Pharmaceutical preparation using sodium 1, 2-naphthoquinone-4-sulfonate (NQS) reagent

Al-Hasnawi Sami W., Nasr Maha S.*

Department of Chemistry, Faculty of Science, University of Kufa, Iraq

*Corresponding Author E-mail: mahasalah2017@gmail.com

Online published on 28 October, 2020.

Abstract

A simple spectrophotometric method was developed to determine the sulfasalazine drug. The method based on the reaction between sodium 1, 2-naphthoquinone-4-sulfonate (NQS) regent with the amino group in the sulfasalazine drug. Maximum absorption of the product was recorded at 456 nm. Beer’s law was obeyed within the concentration range (1-25) ×10−5 M. The molar absorptivity was 1.438 ×104 L. mole−1. cm−1. Molar ratio and Job’s methods revealed that the ratio between the sulfasalazine drug and NQS reagent is 1:1. Average recovery, relative standard deviation (RSD), limit of quantitation (LOQ) and limit of detection (LOD) were 103.6011%, 0.6072%, 0.0273 and 0.0911 M, respectively. The suggested method was also applied to the sulfasalazine tablets (pharmaceutical preparation).

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Keywords

Sulfasalazine, Sodium 1, 2-naphthoquinone-4-sulfonate, Spectrophotometric determination.

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