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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 425) Last page : ( 428)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00083.9

Development and validation of simultaneous spectrophotometric determination of Glibenclamide and Metformin tablets

Annapurna Mukthinuthalapati Mathrusri*, Naik Raghu Raj, Pratyusha Sistla Mounica

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 24 February, 2020.


Two new simple, precise and accurate spectrophotometric methods were developed for the simultaneous determination of Glibenclamide and Metformin combined dosage forms. First order derivative (Method I) and simultaneous equation method (Method II) were developed for the assay of Glibenclamide and Metformin in phosphate buffer (pH 8.0). Linearity was observed 1–80 μg/ml and 1–10 μg/ml in Method I for Glibenclamide and Metformin respectively; 10–100 μg/ml and 1–10 μg/ml in Method II for Glibenclamide and Metformin respectively. Both the methods were validated and applied for the simultaneous determination of Glibenclamide and Metformin tablets.



Glibenclamide, Metformin, First derivative method, Simultaneous equation method, Validation.


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