Design Synthesis and Evaluation of Anticancer Pyrazole Derivatives of Chalcone Scaffold Ms. Kedar M.S1,*, Dr. Shirbhate M.P2, Dr. Chauhan Rajani3, Dr. Sharma Suman4, Dr. Verma Amrita5 1Lecturer, Amrutvahini Institute of Pharmacy, Sangamner 2Principal, Amrutvahini Institute of Pharmacy, Sangamner 3Associate Professor, Banasthali Vidhyapith, Department of Pharmacy, Rajasthan 4Assistant Professor, Banasthali Vidhyapith, Department of Pharmacy, Rajasthan 5Assistant Professor, Graphic Era Hill University, Bhimtal, Nainital *Corresponding Author E-mail: 17vedant17@gmail.com
Online published on 24 February, 2020. Abstract Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.[2] Notable drugs containing a pyrazole ring are celecoxib (Celebrex) and the anabolic steroid stanozolol. Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. Chalcones (1, 3-diaryl propenones), a family of small molecules that are naturally abundant in edible plants, have been found to have antitumor properties for specific cancer cell lines and to interfere in each step of carcinogenesis, including apoptosis. Top Keywords Pyrazole, Chalcone, Anticancer activity and Immunotherapy. Top |