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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 342) Last page : ( 346)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00069.4

Design Synthesis and Evaluation of Anticancer Pyrazole Derivatives of Chalcone Scaffold

Ms. Kedar M.S1,*, Dr. Shirbhate M.P2, Dr. Chauhan Rajani3, Dr. Sharma Suman4, Dr. Verma Amrita5

1Lecturer, Amrutvahini Institute of Pharmacy, Sangamner

2Principal, Amrutvahini Institute of Pharmacy, Sangamner

3Associate Professor, Banasthali Vidhyapith, Department of Pharmacy, Rajasthan

4Assistant Professor, Banasthali Vidhyapith, Department of Pharmacy, Rajasthan

5Assistant Professor, Graphic Era Hill University, Bhimtal, Nainital

*Corresponding Author E-mail: 17vedant17@gmail.com

Online published on 24 February, 2020.

Abstract

Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.[2] Notable drugs containing a pyrazole ring are celecoxib (Celebrex) and the anabolic steroid stanozolol. Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. Chalcones (1, 3-diaryl propenones), a family of small molecules that are naturally abundant in edible plants, have been found to have antitumor properties for specific cancer cell lines and to interfere in each step of carcinogenesis, including apoptosis.

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Keywords

Pyrazole, Chalcone, Anticancer activity and Immunotherapy.

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