Immune Stimulation effects of Pongamia pinnata extracts, an In vitro Analysis Mathayan Manikannan1,*, Suresh Arumugam1, Balamurugan Rangasamy2, Jayaraman Selvaraj3 1Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai-600 119 2Central Research Laboratory, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry-605107 3Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Velappanchavdi, Chennai *Corresponding Author E-mail: maniibms@gmail.com
Online published on 24 February, 2020. Abstract Immune stimulators have been known to augment cell mediated immunity and humoral immunity by affecting the production of various effector molecules such as cytokines generated by activated cells. It is known that these non-specific effects offer protection against different pathogens, including bacteria, fungi, viruses, etc. and constitute an alternative method to the conventional chemotherapy. Plant products are always being a better source for many therapeutic approaches. Indian medicinal plants are known to posses health benefits. Pongamia pinnata (P.pinnata) is a terrestrial medicinal plant has been widely used for treating skin diseases. In this context, we have chosen to explore the newer biological property of P.pinnata. In our previous study we evaluated cytokine stimulation potential of P.pinnta extracts on human PBMCS. In this study we further analyzed the immune cell surface molecules stimulation potential of (P.pinnata) by evaluating specific cell surface markers upon stimulation of P.pinnata extracts on human peripheral blood mononuclear cells (PBMCs). We found that leaf extracts strongly induced co-stimulatory molecules such as B7.2 shows a profound increase in expression is a strong promoter of Th2 response and important immune player in interaction with CD28. Our study offers a positive lead that P.pinnata leaf extracts influences Th2 response which often governs antibody response. Top Keywords Immunotherapy, co stimulatory molecules, B7.1 and B7.2, IL-10. Top |