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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 270) Last page : ( 274)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00055.4

New validated spectrophotometric methods for the combined dosage form of Teneligliptin and Metformin

Annapurna Mukthinuthalapati Mathrusri*, Pratyusha Sistla Mounica, Naik Raghu Raj

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 24 February, 2020.

Abstract

Three new spectrophotometric methods have been developed for the simultaneous determination of combined dosage forms of Teneligliptin and Metformin tablets. Simultaneous equation method (Method A), Q-analysis (Method B) and First derivative (Method C) spectrophotometric methods were developed for the quantification of Teneligliptin and Metformin in sodium hydroxide. Linearity was observed 1–100 μg/ml and 1–35 μg/ml in Method A; 1–60 μg/ml and 1–35 μg/ml in both Method B and Method C for Teneligliptin and Metformin respectively. All the methods were validated as per ICH guidelines and applied for the simultaneous determination of Teneligliptin and Metformin in tablets.

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Keywords

Teneligliptin, Metformin, First derivative method, Simultaneous equation method, Q-Analysis, Validation.

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