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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 250) Last page : ( 254)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00050.5

Novel Stability indicating RP-UPLC Method for simultaneous Determination of Ivabradine and Metoprolol drug materials in bulk and their Pharmaceutical Dosage Forms

Gandi Suresh1,*, Manikandan A.1, Rao S. Venkat2

1Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, India

2SMS Pharmaceuticals Ltd, R&D Centre (A DSIR approved), Gagillapur, Telangana-500047, India, svr.org@gmail.com

*Corresponding Author E-mail: suresh84gandi@yahoo.co.in

Online published on 24 February, 2020.

Abstract

A simple, Accurate, precise method was developed for the simultaneous determination of the Ivabradine and Metoprolol in Pharmaceutical dosage form. Chromatogram was run through SB C8 100 x 3.0mm, 1.8μm. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: Acetonitrile chosen in the ratio 50: 50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature and Wave length was optimized at 30°C and 260 nm independently. Percentage of recovery was obtained as 100.03% and 100.03% for Ivabradine and Metoprolol individually. LOD, LOQ values obtained from regression equations of Ivabradine and Metoprolol were 0.03, 0.08 and 0.12, 0.35 respectively.

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Keywords

New method development, Determination, Ivabradine, Metoprolol, RP-UPLC.

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