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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 203) Last page : ( 208)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00041.4

Hepatoprotective activity of Chloroform and Ethyl acetate extract of Dipteracanthus patulus against Paracetamol induced Hepatotoxicity in rats through Antioxidant mechanism

Yuvaraja K R1, Santhiagu A2,*, Jasemine S3, Kumar K Gopalasathees4

1Assistant Professor, Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India (Affiliated to The Tamil Nadu Dr. M.G.R. Medical University)

2Bioprocess Lab, School of Biotechnology, National Institute of Technology, Calicut, Kerala, India

3Director, One Beat College of Medical Sciences, Bhira, Uttar Pradesh, India

4Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India

*Corresponding Author E-mail: asanthiagu@nitc.ac.in

Online published on 24 February, 2020.


Dipteracanthus patulus (DP) is an important medicinal plant and popularly known as black weed. Dipteracanthus patulus belongs to Acanthaceace family and very important indigenous medicinal plant. The earlier study reported that hepatoprotective activity leaves of DP, hence there is no report on hepatoprotective activity of whole plant of DP and the hepatoprotective phytoconsituents like lupeol, β-carotene, β-sitosterol and rutin are already reported in this plant material. Therefore this current research is aimed to evaluate the hepatoprotective effect of whole plant of Dipteracanthus patulus. The paracetamol induced rat model was used to evaluate the hepatoprotective activity and Silymarin was used for standard. The treatment with the ethyl acetate and chloroform extracts of Dipteracanthus patulus to the paracetamol induced liver toxic rats shows the significant reduction of SGOT, SGPT, ALP, total cholesterol, triglycerides, urea and uric acid levels. However the CAT, GSH, GPx and SOD levels were significant increase in ethyl acetate and chloroform extracts of Dipteracanthus patulus treated paracetamol induced liver toxic rats. Results of current research concluded that the hepatoprotective activity of Dipteracanthus patulus through antioxidant mechanism.



In vivo, Antioxidant, Black weed, Silymarin, Acanthaceace and Hepatoprotective.


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