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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 147) Last page : ( 151)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00029.3

Cystatin-C and Fibronectin as key predictor of glomerulonephritis induced in male rats

Luaibi Hayder Hussein, Al-Abbassi Mustafa Ghazi*, Raoof Israa Burhan**

Department of Pharmacology and Toxicology, Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Iraq

*Corresponding Author E-mail: pharm.mustafa-alabbassi@uomustansiriyah.edu.iq

**israaburhan@uomustansiriyah.edu.iq

Online published on 24 February, 2020.

Abstract

Glomerulonephritis usually reflected as immunological trigger which leading to glomerular cells proliferation and damages in the basement membrane, blood vessel and mesangial endothelium. Podocyte injury is a pathogenesis of nephropathy complication associated with excessive formation of reactive oxygen species and the main reasons of proteinuria. Although, serum creatinine was used in the diagnosis of chronic kidney disease (CKD) but not useful in the early diagnosis of renal failure especially in the individuals with low muscular mass. There is another marker for the estimated of kidney function is newer and more specific than creatinine called Cystatin-C and Fibronectin which is extra extensively utilized.. Statistical analysis of Cystatin-C was expressed as Mean± SEM and P. value for significant indication between all groups. It was revealed significant increased (P<0.05) in the group B (induction group) in relation to kidney deterioration as compared with group A (control group) and group C (treatment group). In addition, the study was appeared significant decreased (P<0.05) in the group C after 4 weeks of liraglutide treatment as comparison with group B however, group C still significantly higher (P<0.05) than normal value of group A. The statistical study of fibronectin was revealed significant increased (P<0.05) in the group B as compared with group A and group C. Furthermore, it was showed significant decreased (P<0.05) of group C than group B and approach of group A (p =0.129). Receiver operating characteristic (Roc) curve was used to identified the ability of the Cystatin-C to diagnose renal injury among ordinary biomarkers (creatinine and urea). It was found more specific (AUC=0.946) but not significantly different from other biomarker which appeared highly AUC (0.941, 0.901) for Creatinine and Urea respectively. There is significant Correlation between Cystatin-C with urea, creatinine, total protein and albumin.

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Keywords

Cystatin-C, Fibronectin, Glomerulonephritis.

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