Comparative quantitative study of the Total anthracen derivatives in combined preparations of Rheum palmatum Nikolaevna Semeniuta Ksenia1,*, Alexandrovich Kurkin Vladimir2, Anatolyevna Shmygareva Anna1, Nikolayevich Sankov Anatoly1 1Orenburg State Medical University, Department of Economics of Pharmacy, Pharmaceutical Technology and Pharmacognosy 2Samara State Medical University, Department of Pharmacognosy, Botany and Phytotherapy *Corresponding Author E-mail: evdkn@mail.ru
Online published on 24 February, 2020. Abstract This paper presents the results of spectrophotometric quantitative determination of total anthracen derivatives in biologically active additives to food of American origin, containing in its composition roots of Rheum palmatum L. The roots of Rheum palmatum contain a sufficient amount of anthracen derivatives (from 2% to 6%), among which dominate: frangula-emodin, rheum-emodin, chrysophanol and rhein. It is the content of these representatives of anthracen derivatives that causes the laxative pharmacological effect of the roots of Rheum palmatum and preparations based on it. In the Russian Federation there are no registered complex drugs of roots Rheum palmatum. Therefore, foreign drugs can serve as a prototype for the development of new laxative combined dosage forms. Quantitative determination of anthracen derivatives in complex preparations of Rheum palmatum was carried out calculated on one of the dominant substances of Rheum palmatum roots-frangulaemodin. The content of anthracen derivatives in the combined preparations of Rheum palmatum roots was from 3.97 to 6% in one tablet or capsule, depending on the indications for the use of the studied drugs. Laxative effect of the drug "Colon herbal cleanser" manufacturer Mason Natural is due to a high single dose-more than 20 mg of anthracen derivatives per reception, while the drug "Herbs and prunes" manufacturer Nature's Life has a lower dosage-6 mg, however, the pharmacological effect is achieved through a combination with prunes. Capsules "Ojibwa Herbal Extract 450mg" manufacturer Now Foods contain an average amount of anthracenes, because the laxative effect is not the main pharmacological action of this drug, but only complements the main anticancer action. Top Keywords Anthracen derivatives, frangula-emodin, Rheum palmatum L, roots, spectrophotometry, standardization. Top |