(3.215.16.238)
[ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4485) Last page : ( 4488)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00772.8

In vitro Anti-Cancer Study of Vitis viniferae, Ixora coccinea and Piper longum Extract on Human Prostate Carcinoma Cells

Deeparani U.1,*, Jayakumari S.2

1Research Scholar, Dept of Pharmacology, VISTAS Vels University, Chennai

2Prof and HOD, Dept of Pharmacognosy, VISTAS Vels University, Chennai

*Corresponding Author E-mail: deepaurolagin@gmail.com

Online published on 24 December, 2019.

Abstract

Because of their chemopreventive action, herbal constituents have got some attention and effectiveness in cost to reduce cancer. Cancer is one of the leading causes of death worldwide. Prostate cancer has become the second highest cause of cancer death and most common malignancy in Western world. The aim of present work is to find out the invitro cell line studies the polyherbal extract constituents on on LN-CAP human Prostate cancer cells. Here 3 drug extracts-vitis viniferae-Grape seed(GSE), Ixora coccinea flower and Piper longum root extract were investigated for their anti-cancer effects against prostate cancer treatment. LN-CAP cells were cultured in DMEM supplemented with1% penicillin, 10% inactivated Fetal Bovine Serum (FBS), humidified atmospheric condition of 5% CO2 at 37°C. By constructing a dose-response curve the IC50 of a drug can be determined. The percentage inhibition of, Piper longum (10–640 μg/ml), vitis viniferae (10–640 μg/ml)and Ixora coccinea (10– 640 μg/ml) treatment of cells resulted in 10–58%, 3–53% and 1–55% growth inhibition respectively. In a concentration and time-dependent manner, cell proliferation decreased. In conclusion, results showed that all drug extracts exhibits cytotoxic effects to LN-CAP cells and it could be a potential anticancer drug against prostate cancer cells. Further studies are needed to carry out to confirm the action of drug extracts.

Top

Keywords

LN-CAP cells, Vitis viniferaeIxora coccinea and Piper longumanticancer activity.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
751,273,943 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.