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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4434) Last page : ( 4437)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00764.9

Catalase and Superoxide Dismutase (SOD) activity in Swiss albino mice treated with ethanolic leaf extract of Madhuca longifolia

Khare Pragati1,*, Kishore Kamal2, Sharma Dinesh Kumar3

1Department of Pharmacy, Shri Ram Murti Smarak, C.E.T., Bareilly, Uttar Pradesh, India

2Department of Pharmacy, M.J.P. Rohilkhand University, Bareilly, Uttar Pradesh, India

3Department of Pharmacy, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, U.K., India

*Corresponding Author E-mail: pragatikhare10@gmail.com

Online published on 24 December, 2019.

Abstract

The leaves of Madhuca longifolia were found crucial for the cure of many diseases. Many of its uses have not been found yet. This research was conducted to investigate the antioxidant activity of the ethanolic extract of dried leaves of Madhuca longifolia in swiss albino mice. A total of forty eight (48) adult swiss albino mice were used. The mice were placed into eight groups: 1, 2, 3, 4, 5, 6, 7 and 8. Each of the groups contained six mice. Groups 4 and 5 were treated orally with doses of 100 and 200mg/kg body weight of the ethanolic extract respectively for 28 consecutive days. Group 1 was the control group and was fed only distilled water and feed. The catalase and superoxide dismutase (SOD) activity obtained in the test groups were significantly higher (P>0.05) than that of the control mice. The observations recorded from this research were dose dependent. The observations of the present research may be utilized to enhance the nootropic and antioxidant activity and can be used for treatment of various diseases.

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Keywords

Madhuca longifolia, Antioxidant activity, Catalase (Cat) and SOD (superoxide dismutase).

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