Users online: 513    [ij] [ij] [ij] 
Email id

Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4165) Last page : ( 4181)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00719.4

New Validated Stability-Indicating RP-HPLC Method for The Determination of Docetaxel and Its Related Substances

Hemchand S.1,*, Babu R. Ravi Chandra1, Annapurna Mukthinuthalapati Mathrusri2

1GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam, India

2GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India

*Corresponding Author E-mail: Hemchand.suryadevara@gmail.com

Online published on 24 December, 2019.


Docetaxel is used for the treatment of castration resistant prostate cancer. Docetaxel is a semi synthetic chemo therapeutic agent extracted from the leaves of Taxus baccata. Two process related substances and four impurities were separated and quantified using Sunfire C18 column (250 x 4.6 mm, 5μm particle size) on gradient mode (40 ± 5°C). A mixture of acetonitrile: 0.01% Acetic acid was used as mobile phase and a mixture of acetonitrile: methanol (1:1, v/v) was used as diluent and the compounds were monitored at 230 nm. Forced degradation studies were performed and the method was validated as per ICH guidelines.



Docetaxel, RP-HPLC, Related substances, Gradient mode, Impurities, Stability indicating.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
514,527,014 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.