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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3945) Last page : ( 3950)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00680.2

Synthesis, Characterization and Study of Cytotoxicity, Antioxidant properties of Isatin based mixed Ligand Complexes

Mohan Mamatha1,*, Veena V2, Reddy K Ramakrishna3

1School of Applied Science, Department of Chemistry, REVA University, Bengaluru, India

2PG Department and Research Studies in Chemistry, Government Science College (Autonomous), Bengaluru, India

3School of Applied Science, Department of Biotechnology, REVA University, Bengaluru, India

*Corresponding Author E-mail: mamathamohan@reva.edu.in

Online published on 24 December, 2019.

Abstract

Present work deals with the study of two Schiff base ligands L1 (L1= Schiff base formed by the condensation of isatin and 2,4-dinitroaniline) and L2 (L2= Schiff base obtained by the condensation of isatin and p-amino toluene) and four mixed ligand complexes of the type [ML1L2X2] where M = Co(II), Ni(II), Cu(II) and Zn (II), X=Cl are synthesized. All the mixed ligand complexes have been analysed by modern techniques such as Elemental analysis, IR, UV-Visible, Conductivity measurements, Magnetic moment measurements, thermogravimetric analysis etc. octahedral geometry is assigned for all the four mixed ligand complexes. The ligands and the mixed ligand complexes are screened for cytotoxicity and antioxidant properties.

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Keywords

Schiff base ligand, Mixed ligand complexes, Isatin, Cytotoxicity, octahedral geometry.

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