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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3899) Last page : ( 3902)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00671.1

The Antimicrobial effect of Iso-amyl Cyanoacrylate: An In-vitro study

Dr. Inbasekaran Dipika1,*, Dr. Sankari M2, Dr. Girija A. S. Smiline3

1Post Graduate Student, Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077

2Professor, Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077

3Asoc. Professor, Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077

*Corresponding Author E-mail: physio_gopal@rediffmail.com

Online published on 24 December, 2019.

Abstract

Introduction

Conventional suture materials tend to accumulate microorganisms which will be the possible cause of surgical wound infection. This led to the use of tissue adhesives like cyanoacrylate. The aim of this study is to assess if iso-amyl cyanoacrylate tissue adhesive had an inherent antimicrobial effect.

Material and Methods

Pure cultures Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa and Candida albicans were seeded on agar plates containing Brain Heart infusion agar. Wells filled with different volumes of iso-amyl cyanoacrylate were prepared. Ampicillin and amphotericin B were used as positive controls. The plates were incubated overnight at 37°C and the zone of inhibition was measured.

Results

Iso-amyl cyanoacrylate exhibited an inhibitory activity against the gram positive organisms and candida but did not show any effect on the gram negative organism.

Conclusion

Iso-amyl cyanoacrylate tissue adhesives have an antimicrobial effect on gram positive organisms and fungi commonly associated with surgical wound infections. This would be an added benefit these tissue adhesives have over conventional suture materials.

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Keywords

Cyanoacrylate, tissue adhesive, antimicrobial, antibacterial.

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