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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3751) Last page : ( 3754)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00642.5

Application of Hot Melt Extrusion for the Solubility Enhancement of a BCS Class II Drug

Kumar Ashay Manisha Shailendra1, Kulyadi Girish Pai1, Mutalik Srinivas1, Kulkarni Vijay Induvadan2, Tippavajhala Vamshi Krishna1,*

1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

2STEER Life India Private Limited, Bangalore, Karnataka, India

*Corresponding Author E-mail: krissrcm@gmail.com

Online published on 24 December, 2019.

Abstract

Solubility enhancement of poorly soluble drugs for improved oral absorption has become a challenging task for the scientists in the development of pharmaceuticals. The main goal of this study is to investigate the effect of the hydrophilic polymers on the poorly water soluble drug to enhance its solubility through the technique of hotmelt extrusion. The drug selected for this study is paracetamol and the hydrophilic polymers selected for this study are polyox, carbopol 980p, and PEG 6000. The drug and the polymer at a ratio of 1:2 was processed through STEERLife twin screw extruder. The obtained solid dispersion was subjected to the saturation solubility study. Among the selected polymers, paracetamol with polyox polymer has shown enhanced solubility followed by PEG 6000 and carbopol 980p.

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Keywords

Solubility enhancement, hot-melt extrusion, twin screw extruder, solid dispersions.

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