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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3703) Last page : ( 3708)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00633.4

Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice

Husen Saikhu A.1,2, Ansori Arif N. M.3, Hayaza Suhailah1, Susilo Raden J. K.1, Zuraidah Ayu A.4, Winarni Dwi1,2, Punnapayak Hunsa1,5, Darmanto Win1,*

1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia

2Animal Histology Laboratory Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia

3Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia

4Faculty of Psychology, Universitas Airlangga, Surabaya, 60115, Indonesia

5Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

*Corresponding Author E-mail: windarmanto@fst.unair.ac.id

Online published on 24 December, 2019.

Abstract

The aims of this study were to determine the effect of various fractions of okra pods extract (VOPE) to the changes of fasting blood glucose, serum insulin, and GLUT4 density on streptozotocin-induced type-2 diabetic mice. This study employed 36 male Balb/c strain mice. The samples were divided into seven groups, KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semipolar), and EP (polar). VOPE and acarbose were administered orally for 14 days in streptozotocin-induced type2 diabetic mice. Mice with type-2 diabetes mellitus were induced by the intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. On 15th day, mice were terminated. The data of fasting blood glucose, serum insulin, and GLUT4 density were analyzed and interestingly it showed that the administration of VOPE could ameliorate the fasting blood glucose, serum insulin, and GLUT4 density. Therefore, it can be suggested that VOPE can be regarded as a promising antidiabetic agent in the streptozotocin-induced diabetic mice.

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Keywords

Abelmoschus esculentus Moench, Fasting Blood Glucose, Serum Insulin, GLUT4 Density, Diabetic Mice.

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