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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3659) Last page : ( 3663)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00624.3

Pharmacokinetic Evaluation of Flavonoid compound (acacetin) Isolated from Gmelina arborea roxb

Nayak Bhabani Shankar1,*, Roy Harekrishna2, Dinda Subas Chandra3, Ellaiah P.4

1Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack-754202, Odisha, India

2Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri Mandal, Guntur – 522503, Andhra Pradesh, India

3Department of Pharmacy, College of Health Sciences, Mekelle University-1871, Mekelle, Ethiopia

4Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore-764002, Koraput, Odisha, India

*Corresponding Author E-mail: hareroy92@gmail.com

Online published on 24 December, 2019.

Abstract

Aim

The flavonoid compound (Acacetin) isolated from fruits of Gmelina arborea was investigated for its pharmacokinetic evaluation to find out the suitability of this compound to be formulated in any suitable dosage form.

Method

The acacetin was administered intravenously and orally in Wistar rats at a dose of 2 and 10 mg/Kg body weight respectively. In a regular interval of specified time, blood samples were collected and bioanalyzed to quantify the drug concentration in the blood sample by using LC-MS. The Cmax, Tmax, T1/2, KE, Ka, and bioavailability (F) of acacetin were determined by mathematically and graphically from plasma concentration-time profile data. Absorption rate constant was determined by the method of residual.

Results

From the i.v. Bolus administration data, acacetin had an area under curve (AUC) is 1.542 μg.h/ml, elimination rate constant (KE) is 0.423 h−1, and half-life (T1/2) is two hour. The oral administration of acacetin showed the peak plasma concentration (Cmax) of 1.668 μg/ml, Tmax is 1 h, AUC is 6.44 μg h/ml, KE is 0.416 h−1, T1/2 is 2 h, absorption rate constant (Ka) is 1.6 h and bioavailability of acacetin was found to be 84%.

Conclusion

From the study it could be concluded that the acacetin possessed relatively greater bioavailability; thus this drug exhibited significant satisfactory pharmacokinetic profile which would be helpful for successful designing of a suitable dosage form formulation.

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Keywords

Flavonoid, Pharmacokinetic, Gmelina arborea, Bioavailability, Acacetin.

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