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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3397) Last page : ( 3404)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00574.2

Design and Characterization of Self Emulsifying Drug Delivery System of Simvastatin: A Technical Note

Singh S. R.1,*, Jadhav K. R.2, Tripathi P. K.1

1Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagaar Railway Station, Ulhasnagar, Maharashtra, India-421003

2 Bharti Vidyapeet's College of Pharmacy, Belapur CBD, Navi Mumbai, Maharashtra

*Corresponding Author E-mail: kurmisushma@gmail.com

Online published on 24 December, 2019.

Abstract

The objective of the present study was to develop self emulsifying drug delivery system of simvastatin to improve solubility and dissolution rate of simvastatin. Simvastatin in a BCS class II drug (poor solubility, good permeability) and low bioavailability (less than 5%). In present study simvastatin self emulsifying drug delivery system was prepared with triacetin as oil, transcutol as surfactant and propylene glycol as co-surfactant. SMEDDS was characterized for stress study, invitro drug release, globule size, zeta potential, polydispersity index, transmission electron microscopy, exvivo permeation study and pharmacodynamic study. Improvement in antihyperlipidimic potential of SMEDDS as compared to plain drug can be attributed to improvement in solubility and drug dissolution rate of simvastatin.

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Keywords

Emulsification, solubility, particle size.

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