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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3301) Last page : ( 3306)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00556.0

Exploring the protective effect of Ascorbic acid on Amoxicillin and Clavulanic acid-induced lipid peroxidation in goat liver homogenate

Pandit Bibhas1,*, Satapathy Trilochan1, Tiwari Pooja2

1Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh-493111, India

2SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh, India, 495009

*Corresponding Author E-mail: bibhas.pandit@gmail.com

Online published on 24 December, 2019.

Abstract

Background

Therapeutic effect of ascorbic acid on amoxicillin and clavulanic acid-induced lipid peroxidation was carried out in got liver homogenates to investigate the relationship between drug-induced toxicity and druginduced lipid peroxidation.

Methods

The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and the only antioxidant-treated group at two hours and six hours of incubation time.

Results

The level of malondialdehyde in the drug-treated group was found to be increased whereas the level of both reduced glutathione and nitric oxide decreased when compared to control. In the drug-antioxidant treated group, the level of malondialdehyde was found to be reduced whereas the extent of reduced glutathione, nitric oxide increased when compared to the drug-treated group.

Conclusion

The present study established the potential of amoxicillin and clavulanic acid to induce lipid peroxidation. On the other hand, ascorbic acid repressed lipid peroxidation to a substantial level. Lipid peroxidation initiation capability of amoxicillin and clavulanic acid might be a contributing factor for their toxicity.

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Keywords

Malondialdehyde, nitric oxide, reduced glutathione, lipid peroxidation, amoxicillin, clavulanic acid, ascorbic acid, antibiotics.

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