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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3265) Last page : ( 3267)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00551.1

In vitro Antihyperglycemic activity of unripe fruits extracts of Artocarpus gomezianus

Fernandes Jennifer, Fernandes Ronald*, M. Vijay Kumar, K. Rajisha, Lobo Ryna V.

Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018

*Corresponding Author E-mail: ronaldfernandes@nitte.edu.in

Online published on 24 December, 2019.

Abstract

Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

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Keywords

in vitro antidiabetic, Artocarpus gomezianus, α-glucosidase, α-amylase enzymes.

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