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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3144) Last page : ( 3150)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00530.4

Colon Targeted Drug Delivery System of Phytoconstituents

Sumithra S*, Vadivu R, Radha R

Department of Pharmacognosy, Madras Medical College, Chennai

*Corresponding Author E-mail: thangasumithra26@gmail.com

Online published on 24 December, 2019.

Abstract

Now a day's world health organization encourage, recommends and promotes traditional, herbal remedies in health care sciences, because these drugs low in cost, easily available and are safe. The main advantage of using phytoconstituents is free from adverse effects where none of the medication can do. However, the physiochemical properties such as poor permeation, poor solubility and non-targeting at the active site creates a barriers which hinders its therapeutic efficacy. So, targeted drug delivery strategies are employed to overcome these barriers and provide uniform drug targeting at the active site in desired concentration and improved therapeutic efficacy. These day's colonic diseases are commonly seen and needs lifelong medical attention. Herbal medicines can play vital role in the treatment of colonic diseases like ulcerative colitis, intestinal bowel syndrome, colon cancer and Crohn's disease. This review article discusses in brief, introduction to targeted drug delivery, factors influence the drug targeting and approaches for enhancing the therapeutic potential of phytoconstituents having wide biological activities.

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Keywords

Colon drug delivery, factors, approach, and phytoconstituents.

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