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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3125) Last page : ( 3132)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00528.6

A Study on Neuropathic Pain: Causes, Grading System, Mechanism-A Review

Akilashree S., Devi P. Brindha*

Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies

*Corresponding Author E-mail: pbrindhadevi@gmail.com

Online published on 24 December, 2019.


Neuropathic pain, the type of pain condition which is caused by the specific nociceptors and is very different from the regular pain. The pain caused is highly intolerable to patients as the pain can be evoked by gentle touch, wind, clothes pressure and puts a great challenge to proceed with day to day activities. The treatments for the neuropathic pain reduces the production of neurotransmitters to some extent which be the cause of intolerable pain, but the faster disease progression is the main concern which can be sorted out by earlier prediction. The efficient grading system is required to differentiate the neuropathic pain condition and to initiate the treatment quickly after the onset of disease. The grading factors give the actual cause, location and the progression of pain. Understanding the mechanism behind the neuropathic pain is very important to carry out the drug formulation, effects of drugs, and distinguishing neuropathic pain from the regular induced pain. It is also required to initiate the treatment shortly after the onset of disease. Here, this review explains about the grading system of neuropathic pain, causes of pain, mechanism and the wide range of drugs involved in the treatment of neuropathic pain.



Nociceptors, neuropathic pain, neurotransmitters.


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