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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 3073) Last page : ( 3077)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00521.3

Targets for Alzheimer's Disease

Dhinakaran S1,*, Tamilanban T2, Chitra V3

1PG Scholar, Department of Pharmacology, SRM College of Pharmacy, SRM Institution of Science and Technology, Kattangulathur-603203, Tamil Nadu, India

2Associate Professor, Department of Pharmacology, SRM College of Pharmacy, SRM Institution of Science and Technology, Kattangulathur-603203, Tamil Nadu, India, veera.srm@gmail.com

3Professor and Head of the Department Department of Pharmacology, SRM College of Pharmacy, SRM Institution of Science and Technology, Kattangulathur-603203, Tamil Nadu, India, velchitram74@gmail.com

*Corresponding Author E-mail: dhina1676@gmail.com

Online published on 8 August, 2019.

Abstract

AD is predominant of causing mortality across the world. Various type of hallmarks has been exploring in this disease, like aggregates of β-amyloid, hyperphosphorylated tau proteins, dyshomeostasis of biometals, oxidative stress, reduction in Ach, etc. There is no test to diagnose AD and it not simple. The majority of putative diseasemodifying treatments in development for Alzheimer's disease directed against the amyloid-β (A β) peptide. AD allowed for the development of the first generation of therapies that are somewhat specific for this disorder. Acetylcholine esterase, β-secretase, tau protein and NMDA are the essential targets involves in the treatment of Alzheimer's disease. AChE inhibitors and NMDA blockade have proven that higher efficacy levels in AD and many authors considering that as "symptomatic" treatments.

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Keywords

Alzheimer's diseases, β-amyloid, acetylcholine, a cholinesterase inhibitor, NMDA.

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