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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 3063) Last page : ( 3067)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00519.5

A Review on Viperin Evoke Exponential Interferon Radical SAM Enzyme and Macrophages Inducibility to treat viral Infections

Batta Prasanth Sai1,*, Jarugula Nagaraja2, Samudrala Mahanthi1, Manchineni Prasada Rao3

1Student, Department of Pharmacy Practice, M. A. M College of Pharmacy, Kesanupalli, Narasaraopeta, AP

2Assistant Professor, Department of Pharmacy Practice, M. A. M College of Pharmacy, Kesanupalli, Narasaraopeta, AP

3Principal, Department of Pharmacy Practice, M. A. M College of Pharmacy, Kesanupalli, Narasaraopeta, AP

*Corresponding Author E-mail: prasanthsai790@gmail.com

Online published on 8 August, 2019.

Abstract

Viral infections are one of the major health issues prevailing now a day. They demand new therapeutic strategies. Viperin is a virus inhibitory protein which is present in the endoplasmic reticulum of mammalian cells. Viperin is a member of radical S-adenosyl methionine and is a super family of enzymes. Viperin is an interferon inducible protein which involves in the inhibition of replication and budding of a wide range of both DNA and RNA viruses including chikungunyavirus, bunyamwera virus, tick-born encephalitis virus, influenza virus, human cytomegalo virus, west nile virus, hepatitis-C virus, sindbis virus, Japanese encephalitis virus, HIV and others. Viperin is an enzyme which helps in converting cytidine triphosphate (CTP) to 31-deoxy-3141didehydro CTP (ddhCTP) so that the viral replication stops. CTP is very much essential for the viral replication. This mechanism occurs through S-adenosyl methionine (SAM) dependent radical mechanism which is similar to other members of the RS super family. In innate signaling Viperin plays a main role by both direct inhibition and replication and by budding and it destroys the actin cyto-skeleton which further leads to increase HCMV. It is an best example to determine the anti-viral property.

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Keywords

Interferon, radical SAM, macrophages, viral infections, interferon, endoplasmic reticulum, cytidine triphosphate (CTP), and interferon stimulated gene (ISG).

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