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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 3053) Last page : ( 3058)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00517.1

Synthesis, Characterization and Antibacterial activity of Disulfide and Sulfone Compounds Derivatives from Benzimidazole

Redayan Muayedahmed1,*, ali Ali Hussein1, Monem Zainabalaa1

1Department of Chemistry, College of Education for Pure Sciences, Diyala University, Diyala, Iraq

*Corresponding Author E-mail: mredayan@gmail.com

Online published on 8 August, 2019.

Abstract

This study aimed to prepare a series of disulfide and sulfone compounds derivatives from benzimidazole. The target compounds were prepared by three steps: First step comprise synthesis of 2-mercaptobenzimidazole derivatives from reaction of 4-(un)substituted-o-pheneylenediamine with carbon disulfide, In the second step: Alkylation of the 2-mercaptobenzimidazole derivatives with different alkyl halides to obtain thioether compounds. Final step: include oxidation of 2-mercaptobenzimidazole derivatives to yielded disulfide compounds while oxidation of thioether compounds gave sulfone derivatives by using hydrogen peroxide as oxidizing agent. The chemical structures of all synthesized compounds were confirmed by FT-IR and some by 1H and 13C-NMR. Some selected compounds were tested in vitro for their antibacterial activity by disc diffusion method against two types of Gram-positive bacteria namely (Staphylococcous aureus, Bacillus subtilis) and Gram-negative bacteria namely (Pseudomonas aeruginosa, Escherichia coli). The results displayed that most of the prepared compounds have a good antibacterial activity when compared with the standard antibiotic ampicillin and ciprofloxacin.

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Keywords

2-mercaptobenzimidazole, sulfone compounds, thioether, alkylation.

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