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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 3029) Last page : ( 3032)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00512.2

Development and Validation for estimation of Abiraterone acetate in Bulk and Pharmaceutical Dosage Form by UPLC

Goud V. Mohan*, Rani B Sandhya, Sharma JVC, Sirisha P.

Department of Pharmaceutical Analysis, Joginpally B.R Pharmacy College, Yenkapally, Moinabad, R.R. Dist. Telangana

*Corresponding Author E-mail: mohanvanga@yahoo.com

Online published on 8 August, 2019.


A simple, Robust, stability indicated method was developed for the estimation of Abiraterone by RP-UPLC technique. Chromatographic conditions used are, stationary phase SB C8 100 × 3.0 mm, 1.8μ. Mobile phase 0.01N NaH2PO4: Acetonitrile in the ratio of 60: 40v/v and flow rate were maintained at 0.3 ml/min, detection wave length was 235 nm, and column temperature was set to 30°C. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150% levels, R2 value was found to be as 0.999. Precision was found to be 0.6 for repeatability and 1.1 for intermediate precision. LOD and LOQ are 0.09μg/ml and 0.27μg/ml respectively. Degradation studies of Abiraterone were done, in all conditions and it is within the acceptable range.



UPLC, Abiraterone Acetate, Mobile Phase, Method development.


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