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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 3024) Last page : ( 3028)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00511.0

Formulation and Evaluation of Immediate release tablets of Topiramate using Sodium starch glycolate

Panda Kanhu Charan1,*, Panda Niranjan1, Sahoo Chinmaya Keshari2, Bhaskar Jimidi3, Ramana D. Venkata4

1Department of Pharmaceutics, Anwar-ul-Uloom College of Pharmacy, Hyderabad, Telangana-500001

2Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University). Maisammaguda, Secunderabad, Telangana-500014

3Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri, Kothagudem, Telangana-507115

4Department of Pharmaceutical Technology, Samskruti College of Pharmacy, Kondapur, Ghatkesar, Medchal, Telangana, India

*Corresponding Author E-mail: kanhuchpanda@gmail.com

Online published on 8 August, 2019.

Abstract

The aim of the current study was to develop immediate release tablets (IRT) of topiramate using different concentrations of sodium starch glycolate (SSG) as super disintegrant. Four different formulations of IRT were prepared using wet granulation method. Different pre compression and post compression characterization of tablet was carried out. In vitro drug release studies were carried out in USP II paddle type dissolution apparatus for different formulation and the batch containing 7.5 mg of SSG per tablet gave maximum amount of drug release of 90.76% at the end of 50 mins. Drug and excipients compatibility studies were carried out through FTIR spectroscopy. FTIR spectroscopy studies revelled that there is no interaction between drug and different excipients used in formulation. Short term stability studies (at 40±2ºC/75±5% RH) on the best formulation indicated that there were no significant changes in release profile and drug content after a period of one to three month. Among all the formulations, F4 formulation was finally optimized.

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Keywords

IRT, topiramate, SSG, drug release, FTIR spectroscopy.

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