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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2922) Last page : ( 2928)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00492.X

Design and Development of Valsartan Loaded Nanostructured Lipid Carrier for the Treatment of Diabetic wound Healing

Jaiswal Ayush**, Senthil V.*, Das Tamal Kusum

1Department of Pharmaceutics, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education and Research, Mysuru

*Corresponding Author E-mail: senthil.v@jssuni.edu.in

**ayushjaiswal425@gmail.com

Online published on 8 August, 2019.

Abstract

Diabetes mellitus is a group of metabolic diseases identified by hyper glycaemia that results from defects in insulin secretion, insulin action or both. It can also be referred as metabolic disorder. The main objective of this research is to enhance the protection of wound healing from the valsartan loaded Nanostructure Lipid carrier. Valsartan is the angiotensin II antagonist drug, which is of BCS class II category. Nanostructure lipid carrier is a colloidal carrier system which is having many advantages such as improvement in Bioavailability, Increase in the solubility and therapeutic efficacy. The prepared Nanostructure lipid carrier was consisting of palmitic acid as solid lipid and soya oil as liquid lipid were prepared by melt emulsification method. Optimization and Characterization of Valsartan loaded NLCs have been done by DSC, FT-IR, Particle size, Zeta potential, Scanning Electron microscopy, Stability study, Entrapment efficiency, Release kinetics and In-vitro drug release studies. The In-vivo have also been done for the treatment of Diabetic wound healing. In Conclusion, it is shown that the valsartan loaded Nanostructure lipid carrier formulation was very effectively for the treatment of Diabetic wound Healing.

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Keywords

Diabetic wound healing, Nanostructured lipid carrier, Valsartan; Drug release, In-vivo Studies.

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