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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2851) Last page : ( 2856)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00480.3

Determination of Dimenhydrinate and Chlorpheniramine Maleate in Pharmaceutical Forms by new Gas Chromatography Method

Alghazal Muhamad Esam Kaf1, Alrouh Fadi2, Bitar Yaser1, Trefi Saleh1,*

1Pharmaceutical Quality and Pharmaceutical Chemistry Department-Faculty of Pharmacy, University of Aleppo, Syria

2Organic Chemistry Department-Faculty of Medicine, University of Al-Hawash, Syria

*Corresponding Author E-mail: salehtrefi@yahoo.com

Online published on 8 August, 2019.


A specific and highly sensitive gas chromatographic method was developed for the simultaneous determination of chlorpheniramine maleate and dimenhydrinate using one drug as internal standard for the other one. The chromatographic conditions are aTRB-5-625 capillary column (60m × 0.25 mm i.d0.25μm film thickness) and nitrogen as a carrier gas at a flow rate of 1.0 mL min. The oven temperature was programmed at 230°C for 1 min, with a rise of 20°C min up to 250°C (held for 7 min). The injector and detector port temperatures were maintained at 290°C. Detection was carried out using flame ionization detector. Results of assay and recovery studies were statistically evaluated for its accuracy and precision using one drug as internal stander for the other one and vice versa.


The objective of this study was to develop and validate a gas chromatographic method to separate and assay to antihistamine drugs, dimenhydrinate and chlorpheniramine maleate in pharmaceutical forms. This method was a practical additional choice in quality control laboratories.



Chlorpheniramine maleate, dimenhydrinate, gas Chromatography.


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