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Antioxidant and Hepatoprotective Activity of Root extract of Baliospermum montanum (Willd) Muell Arg Ahirwar B1,*, Ahirwar D2 1Institute of Pharmacy, Guru Ghasidas University, Bilaspur (C.G.), India 2School of Pharmacy, Chouksey Engineering College, Bilaspur (CG) India, dheeraj_ahirwar@rediffmail.com *Corresponding Author E-mail: ah_bharti@yahoo.com
Online published on 8 August, 2019. Abstract The hydroalcoholic extract of Baliospermum montanum Muell Arg root was screened for their possible hepatoprotective and antioxidant effect. Carbon tetrachloride (CCl4) and ethanol were used to produce liver toxicity. The hydroalcoholic extract of plant root was administered and biochemical parameters were estimated. Concurrently, silymarin was used as a standard hepatoprotective agent. The root extract was also studied for in vitro total antioxidant capacity by ABTS assay. The results indicated that biochemical parameter changes produced by CCL4 and ethanol were restored to normal by the hydroalcoholic extract. The hydroalcoholic extract showed significant (p<0.05) protection of liver cell against CCL4 and ethanol-induced hepatocellular injury in a dose-dependent manner. The effects of hydroalcoholic extract were comparable with silymarin. Hepatoprotection produced by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation. The antioxidant potential of the extract may be attributed to the presence of phenolic and flavonoid compounds. The root extract of Baliospermum montanum Muell Arg. exhibited significant antioxidant and hepatoprotective activity. Top Keywords Antioxidants activity, Ethanol, Hepatoprotective activity, Baliospermum montanum Muell Arg. Top | |
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