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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2453) Last page : ( 2460)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00411.6

Effect Antioxidant and Serotonin Level in the Sera on Type II Diabetes Mellitus Males Patients and Compare with Control Group

Abbas Ahmed Chyad1,*, Al-Kraity Wijdan Rajh Hamza1,**, Abbas Ebtihal Chiad2,***

1Department of the Pathological Analysis Techniques, College of Al-Toosi University

2Department of Medicine, Najaf, Iraq

*Corresponding Author E-mail: ahmedchyad90@gmail.com



Online published on 8 August, 2019.


The study is intended to asses serum levels of Serotonin, malondialdehyde (MDA) and glutathione (GSH) in type 2 diabetic mellitus patients in comparison healthy groups of males, also correlation among Serotonin, MDA and GSH of DM patients. The study was conducted on selected 60 type 2 diabetic patients of males that attending to the diabetes mellitus center in Al-Sadder Teaching City in Al-Najaf province, Iraqi and a group of 60 apparently healthy subjects of males were included as a control group. The D M patients are divided into three groups of ages (15-19y), (20-39y) and (40–60 y). The Study was carried out from June 2018 to October 2018. The patients ’age was ranging from 15 to 60 years old. The results also revealed that significant increase (p<0.05) in serum levels Serotonin and MDA in diabetic patients in comparing with healthy groups, while a significant decrease (p<0.05) in serum level GSH in diabetic patients in comparing with healthy groups. The results show that serum Serotonin level no significant (p>0.05) between (20-39y) and (40-60y) ages of D M patients, But there is a significant increase (p<0.05) in these ages groups than the ages (15-19y). The results show that serum MDA level increase significantly (p<0.05) with increasing age of patients and the ages (40-60y) are highly significant(p<0.05) than (20-39-54y) and (15-19y). The results show that serum GSH level no significant (p>0.05) between the ages (20-39y) and (40-60y) groups of D M patients, But there is a significant increase (p<0.05) in the ages (15-19y) than the ages (20-39y) and (40-60y) groups. The results have been shown a significant positive correlation (P<0.05) between serotonin and MDA in DM patients, and a significant negative correlation (P<0.05) between (serotonin and GSH), (MDA and GSH) in DM patients.


The present study concluded that Serotonin, MDA and GSH were marker for detection and diagnosis of type 2 diabetic mellitus males patients.



Type II Diabetes mellitus, Oxidative stress, Serotonin, MDA and GSH.


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