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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2175) Last page : ( 2181)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00362.7

Studies on Antimicrobial activity of a metabolite produced by Streptomyces malaysiensis isolated from Termite Mound Soil

Kolipaka Uma Maheswari1,*, Sankar G. Girija2

1Assistant Professor, Pharmaceutical Biotechnology Department, Narasaraopet, Guntur, A.P-522601

2Professor, A.U. College of Pharmaceutical Sciences, Visakhapatnam

*Corresponding Author E-mail: fromuma7@gmail.com, fromsudha7@gmail.com

Online published on 8 August, 2019.


To discover novel secondary metabolites, our approach is to investigate unexplored regions of the world with the aim of isolating bioactive actinomycetes from the termite mounds soil sample. Actinomycetes are soil microorganisms. They are a type of bacteria. They are the same as each microorganism and fungi, and have characteristics linking them to both groups Actinomycetes square measure typically believed to be the missing biological process link between microorganism and fungi, however they need more characteristics in common with microorganism than they are doing fungi.13 actinomycetes and 3 fungal isolates were screened from the soil sample and out of them 6 actinomycetes showed anti microbial activity by agar-overlay method, Cross streaking method and Cup plate method. By the Agar overlay method we can assure that the isolate TMS 1A is having anti bacterial activity and anti fungal activity by measuring the inhibition zone diameter as 40mm and 35mm respectively. Cross streaking method of the active compound obtained from isolate TMS 1A shows that it is having antimicrobial activity against Gram +ve, Gram-ve bacteria and fungi. Cup plate assay of the active compound obtained from isolate TMS 1A shows that it is having anti bacterial activity. Results from anti microbial activity revealed that our isolate TMS 1 08 09 2010 1A was found to have broad spectrum of anti microbial activity on both (Gram + ve and Gram-ve) bacteria and fungi. Further investigation is required to extract the Bioactive metalbolites from Streptomyces malaysiensis.



Actinomycetes, anti microbial activity, microorganism, Termite, Isolate.


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