Antidiabetic Effect of the Combination of Garlic Peel Extract (Allium sativum) and Onion Peel (Allium cepa) in Rats with Oral-Glucose Tolerance Method Lolok Nikeherpianti1,*, Mashar Harlyanti Muthmainnah2,**, Annah Itma2, Saleh Ahmad1,***, Yuliastri Wa Ode1,****, Isrul Muhammad1,***** 1Departement of Pharmacy, STIKES Mandala Waluya, Kendari 2Department of Nutrition, Health Polytechnic of Health Ministry of Palangka Raya, Indonesia *Corresponding Author E-mail: nikeherpianti.apt@gmail.com
**harlyantimuthmainnah@gmail.com
***ahmadsalehfarmasimw@gmail.com
****waodeyuliastri@yahoo.com
*****isrulfar@gmail.com
Online published on 8 August, 2019. Abstract Diabetes mellitus threat in the middle of the society has become a scare disease because in each 10 seconds in the world people die because the complication of that disease. The application of natural drug has been applied empirically by the society, such as the application of the extract of garlic peel and onion peel each has been reported has hypoglycemic effect and potential as an antioxidant which can repair damage cell body, include pancreas. The aim of this study is to understand the effect of the combination of garlic peel extract and onion peel extract to the decreasing of blood glucose level in normal rats compare to the combination of metformin and glibenclamide and to the decreasing of blood glucose level in rats induces diabetic drug compare to pen insulin. This laboratory experimental study aims to understand the anti-diabetic effect of the combination of garlic (Allium sativum) peel extract and onion (Allium cepa) peel extract in rats induced glucose per orally and alloxan. Test of anti-diabetic effect, test animals are divided into 7 group, 3 groups to oral glucose tolerance test in normal rats (negative control, positive control, and extract combination) and 4 groups to test in rats induced diabetes (negative control, positive control, diabetic control, and combination extract). The result of oral glucose tolerance test to the normal groups reveal that the combination of this extract significantly decrease blood glucose level compare to the negative control group specifically in the 0, 30th, 60th, and 90th minutes (p<0.05). In the test to the diabetic induces rats reveal that the combination of this extract also significantly decrease the blood glucose level compare to diabetic group (p<0.05), meanwhile the result is not real difference to the positive control group (p>0.05). This study shows that the combination of peel garlic extract and onion peel extract have the ability to decrease the blood glucose level both in normal rats induced glucose and rats induced diabetic. Top Keywords Garlic peel, Allium sativum, onion peel, Allium cepa, Diabetes Mellitus, oral glucose tolerance. Top |