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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2145) Last page : ( 2152)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00356.1

In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities

Zin Thant1, Sivakumar J.2, Sundaram C. Shanmuga3, Rao U. S. Mahadeva1,*

1Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, Malaysia

2PG and Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai-603103

3PG and Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai-603103

*Corresponding Author E-mail: raousm@gmail.com

Online published on 8 August, 2019.

Abstract

Aim

The present investigation gives a detailed report on the analysis of the bioactive compound isolated from the sand crab Emerita asiatica is having better relation with vasoconstriction.

Methods

The sand crab Emerita asiatica were collected from Thiruvidandhai beach located on the Kanchipuram District, Tamil Nadu, India, 41 K.M away from Chennai, on the East Coast Road route to Mahabalipuram. Sand crabs were collected by hand picking method. From the muscle mass of the Crab the organic compound was isolated by GC-MS analysis. Molecular docking was also performed to identify the protein ligand responsible for the constriction of blood vessels.

Results

The isolated bioactive compound was identified as phenylephrine, an α1 adrenergic receptor which has the potential to lead the molecule for the vasoconstriction. In vitro studies of antibacterial activities clearly indicated that the different concentrations of phenylephrine have the antibacterial activity against the bacteria such as Klebsiella pneumoniae and Staphylococcus aureus.

Summary

The present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs from marine organisms. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the vasoconstriction.

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Keywords

Emerita asiaticaKlebsiella pneumoniae, Phenylephrine, Staphylococcus aureus, vasoconstriction.

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