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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2141) Last page : ( 2144)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00355.X

Synthesis of Some Novel Flavanones and Evaluation of Antioxidant Activities

Bhat K. Ishwar, Kumari Ranee, kumar Abhishek, Kumar Pankaj*

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore-575018, Karnataka, India

*Corresponding Author E-mail: pankajpgr@gmail.com

Online published on 8 August, 2019.

Abstract

The novel series of substituted flavanones were synthesized by reacting various 2-hydroxy chalcones. The intermediate 2-hydroxy chalcones were synthesized by Claisen-Schmidt condensation reaction. Flavanones were prepared by refluxing 2-hydroxychalcones in ethanol in presence of conc. H2SO4. All the synthesized compounds (RF1-RF9) were assigned on the basis of IR, 1H-NMR and MASS spectral data. These synthesized compounds were evaluated for their antioxidant activity by two different methods, DPPH and nitric oxide method. The compounds RF1, RF2, RF6, and RF7, RF8 showed very good activity when compared to the standard.

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Keywords

2-hydroxy chalcones, flavanones, antioxidant, DPPH, nitric oxide.

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