(3.236.65.63)
Users online: 2543    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2089) Last page : ( 2092)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00346.9

Inhibitory potential of Amaranthus viridis on α-amylase and glucose entrapment efficacy In vitro

Helen P. A. Mary1, Bency B. Jesvin2,3,*

1Assistant Professor, Department of Biotechnology, Malankara Catholic College, Kanyakumari District-629153, Tamilnadu, India

2PhD Research Scholar, Department of Biotechnology, Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli, Tamilnadu, India

3Research centre, Malankara Catholic College, Kanyakumari District-629153, Tamilnadu, India

*Corresponding Author E-mail: bencyboaz@gmail.com

Online published on 8 August, 2019.

Abstract

Type 2 Diabetes which prevails globally increasing at an alarming rate, is characterized by hyperglycemia where blood glucose levels remain elevated due to poor cellular glucose uptake and metabolism. One way to treat this disease is by α-amylase inhibitors and glucose retention in intestine for longer period. The present study was designed to determine the in vitro antidiabetic potential of Amaranthus virdis extracts. Antidiabetic action was confirmed by the inhibitory effects of the A.viridis extracts on α-amylase activity and significant glucose entrapment ability. The methanolic extract of A. viridis leaves exhibited the highest glucose retention ability of 47.05% (40.125μg/mL) within the dialysis tube which mimics human intestine. Water extract of A. Viridis stem showed the most significant inhibition effect on α-amylase activity (100%) compared to other extracts after 15 minutes of incubation, with IC50 value of (5.058±0.41μg/mL) and which was even equally active to the standard acarbose drug used in the current analysis. Interestingly, the methanol extract of leaf exhibited notable efficacy both on glucose diffusion inhibition and inhibition of alpha amylase as well. This study suggests for further in vivo research to check their activity and toxicity within biological systems and also for the isolation of bioactive inhibitory compounds for novel drug discovery.

Top

Keywords

Antidiabetic activity, Amaranthus viridisIn vitro, Glucose diffusion inhibition, Alpha amylase inhibition.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
598,511,638 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.